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Simple electrochemical DNA biosensor for detection of DNA damage induced by hydroxyl radicals

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F15%3A10328322" target="_blank" >RIV/00216208:11310/15:10328322 - isvavai.cz</a>

  • Result on the web

    <a href="https://web.natur.cuni.cz/analchem/isc-mac/" target="_blank" >https://web.natur.cuni.cz/analchem/isc-mac/</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Simple electrochemical DNA biosensor for detection of DNA damage induced by hydroxyl radicals

  • Original language description

    A novel simple electrochemical DNA biosensor based on a glassy carbon electrode was prepared by adsorbing low molecular weight double-stranded DNA from salmon sperm onto the electrode surface as a biorecognition layer. The biosensor was used for detection of DNA damage by hydroxyl radicals. Hydroxyl radicals are well-known reactive oxygen species inducing the oxidative stress in DNA. They can attack all the molecules, including DNA, and play a major role in the DNA oxidative damage. They were generated for our purposes electrochemically on the surface of a boron-doped diamond film electrode. A complex characterization of the specific damaging event was then obtained using a combination of several electrochemical detection techniques: cyclic voltammetry, square-wave voltammetry, and electrochemical impedance spectroscopy.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    CB - Analytical chemistry, separation

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GBP206%2F12%2FG151" target="_blank" >GBP206/12/G151: Center of novel approaches to bioanalysis and molecular diagnostics</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    PROCEEDINGS OF THE 11TH INTERNATIONAL STUDENTS CONFERENCE "MODERN ANALYTICAL CHEMISTRY"

  • ISBN

    978-80-7444-036-6

  • ISSN

  • e-ISSN

  • Number of pages

    4

  • Pages from-to

    19-22

  • Publisher name

    CHARLES UNIV, FAC SCIENCE

  • Place of publication

    PRAGUE 2

  • Event location

    Prague

  • Event date

    Sep 22, 2015

  • Type of event by nationality

    EUR - Evropská akce

  • UT code for WoS article

    000383853900004