Use of 6-O-mono-substituted derivatives of β-cyclodextrin-bearing substituent with two permanent positive charges in capillary electrophoresis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F16%3A10325009" target="_blank" >RIV/00216208:11310/16:10325009 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1515/chempap-2016-0053" target="_blank" >http://dx.doi.org/10.1515/chempap-2016-0053</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/chempap-2016-0053" target="_blank" >10.1515/chempap-2016-0053</a>

Result language

angličtina

Original language name

Use of 6-O-mono-substituted derivatives of β-cyclodextrin-bearing substituent with two permanent positive charges in capillary electrophoresis

Original language description

This study details the use of two permanently positively charged mono-substituted beta-cyclodextrin derivatives, 6(I)-deoxy-6(I)-(N,N,N',N',N'-pentamethyl-ethylene-1,2-diammonio)-cyclomaltoheptose dichloride (PEMEDA-beta-CD) and the newly synthesised 6(I)-deoxy-6(I)-(N,N,N',N',N'-pentamethylpropylene-1,3-diammonio)-cyclomaltoheptose (PEMPDA-beta-CD) as chiral selectors in capillary electrophoresis. Cyclodextrin (CD) derivatives were tested as additives in various buffers at various pH values with the optional addition of an organic modifier. Fourteen anionogenic analytes were tested, including native amino acids, N-blocked amino acids and profens, which were detected using a UV-VIS detector at optimal wavelengths of 214 nm, 254 nm or 280 nm. A borate buffer (15 mmol L-1) at pH 9.5 without the addition of an organic modifier was chosen as a suitable background electrolyte. In addition, the effect of the concentration of the chiral selector on the separation and enantioseparation of selected analytes was monitored. The additions of cyclodextrin derivatives varied within the concentration range of 0.0-5.0 mmol L-1. Both chiral selectors were suitable for the enantioseparation of N-Boc-D, L-tryptophan, which was already separated on the baseline at 0.5 mmol L-1 concentration of the chiral selector. (c) 2016 Institute of Chemistry, Slovak Academy of Sciences

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

<a href="/en/project/GA13-01440S" target="_blank" >GA13-01440S: Chiral supramolecular polymers based on derivatized cyclodextrins as a new environment for capillary separation techniques</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemical Papers

ISSN

0366-6352

e-ISSN

—

Volume of the periodical

70

Issue of the periodical within the volume

9

Country of publishing house

SK - SLOVAKIA

Number of pages

11

Pages from-to

1144-1154

UT code for WoS article

000378599000002

EID of the result in the Scopus database

2-s2.0-84974555859