Enantioseparation of Tröger?s base derivatives by capillary electrophoresis using cyclodextrins as chiral selectors

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F13%3A43895065" target="_blank" >RIV/60461373:22340/13:43895065 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1002/chir.22148" target="_blank" >http://dx.doi.org/10.1002/chir.22148</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/chir.22148" target="_blank" >10.1002/chir.22148</a>

Result language

angličtina

Original language name

Enantioseparation of Tröger?s base derivatives by capillary electrophoresis using cyclodextrins as chiral selectors

Original language description

The enantioseparation of seven Troger's base derivatives (TBs) was carried out by capillary electrophoresis using alpha-, beta-, and gamma-cyclodextrins as chiral selectors and phosphate at 20 mmol/l concentration, pH 2.5, as background electrolyte. Themethod was optimized with respect to the concentration of chosen chiral selectors (0-50 mmol/l) and the amount of organic solvent (acetonitrile, 0-25 % (v/v)) in the electrolyte. The results indicate that all the studied variables, i.e., type of chiral selector, its concentration, and the amount of the added organic solvent, have a significant impact on the enantioseparation of the studied TBs. The best results for the majority of the separated TBs were obtained utilizing beta-cyclodextrin at 5 mmol/l concentration and with various amounts of acetonitrile added ranging from 5 to 15% (v/v) in the background electrolyte. For the two smallest studied TBs, gamma-cyclodextrin with 10% (v/v) acetonitrile also provided good resolution.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

<a href="/en/project/GAP206%2F12%2F0453" target="_blank" >GAP206/12/0453: Affinity capillary electromigration methods for selective nanoanalysis of biomolecules and investigation of their interactions</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chirality

ISSN

0899-0042

e-ISSN

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Volume of the periodical

25

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

379-383

UT code for WoS article

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EID of the result in the Scopus database

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