Separation of cetirizine enantiomers by capillary electrophoresis with a dual selector system based on borate-glucose complexes and sulfated-beta-cyclodextrin

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F19%3A73597890" target="_blank" >RIV/61989592:15310/19:73597890 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0039914019300682" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0039914019300682</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.talanta.2019.01.097" target="_blank" >10.1016/j.talanta.2019.01.097</a>

Result language
angličtina
Original language name
Separation of cetirizine enantiomers by capillary electrophoresis with a dual selector system based on borate-glucose complexes and sulfated-beta-cyclodextrin
Original language description
The aim of this study was to focus on the reduction of chiral selector concentration, sulfated-beta-cyclodextrin, in an attempt decrease the running costs associated with separating cetirizine enantiomers by capillary electrophoresis. The decrease in the concentration of chiral selector was achieved by adding D-glucose to the background electrolyte, which consisted of sodium borate. Optimal separation of cetirizine enantiomers was obtained in the electrolyte containing 500 mmol L-1 borate pH 9.5 with 1.0 mg mL(-1) sulfated-beta-cyclodextrin, and 1000 mmol L-1 D-glucose. This means a 15-fold reduction in the concentration of sulfated-beta-cyclodextrin. The mechanism of the separation in this electrolyte was investigated using direct injection mass spectrometry. The electrolyte of borate, D-glucose, and sulfated-beta-cyclodextrin forms a dual selector system, in which one selector is represented by the sulfated-beta-cyclodextrin and the second selector is represented by the D-glucose-borate complexes.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry

Project
<a href="/en/project/LO1305" target="_blank" >LO1305: Development of the center of advanced technologies and materials</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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