Identification of STAT3 and STAT5 Proteins in the Rat Suprachiasmatic Nucleus and the Day/Night Difference in Astrocytic STAT3 Phosphorylation in Response to Lipopolysaccharide
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F16%3A10333271" target="_blank" >RIV/00216208:11310/16:10333271 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/jnr.23673" target="_blank" >http://dx.doi.org/10.1002/jnr.23673</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jnr.23673" target="_blank" >10.1002/jnr.23673</a>
Alternative languages
Result language
angličtina
Original language name
Identification of STAT3 and STAT5 Proteins in the Rat Suprachiasmatic Nucleus and the Day/Night Difference in Astrocytic STAT3 Phosphorylation in Response to Lipopolysaccharide
Original language description
Signal transducers and activators of transcription (STAT) proteins regulate many aspects of cellular physiology from growth and differentiations to immune responses. Using immunohistochemistry, we show the daily rhythm of STAT3 protein in the rat suprachiasmatic nucleus (SCN), with low but significant amplitude peaking in the morning. We also reveal the strong expression of STAT5A in astrocytes of the SCN and the STAT5B signal in nonastrocytic cells. Administration of lipopolysaccharide (LPS) acutely induced phosphorylation of STAT3 on Tyr705 during both the day and the night and induced phosphorylation on Ser727 but only after the daytime application. The LPS-induced phospho-STAT3 (Tyr705) remained elevated for 24 hr after the daytime application but declined within 8 hr when LPS was applied at night. (C) 2015 Wiley Periodicals, Inc.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GAP303%2F12%2F1137" target="_blank" >GAP303/12/1137: The role of the STAT signalling pathway in the rat circadian system</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neuroscience Research
ISSN
0360-4012
e-ISSN
—
Volume of the periodical
94
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
99-108
UT code for WoS article
000363749400009
EID of the result in the Scopus database
—