Highly Diastereo- and Enantioselective Synthesis of alpha-Spiro-delta-lactams by an Organocascade Reaction

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F17%3A10359786" target="_blank" >RIV/00216208:11310/17:10359786 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/ejoc.201700193" target="_blank" >http://dx.doi.org/10.1002/ejoc.201700193</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ejoc.201700193" target="_blank" >10.1002/ejoc.201700193</a>

Result language
angličtina
Original language name
Highly Diastereo- and Enantioselective Synthesis of alpha-Spiro-delta-lactams by an Organocascade Reaction
Original language description
An asymmetric synthesis of alpha-spiro-delta-lactams by an organocascade reaction of easily accessible starting materials has been accomplished. The catalytic sequence begins with enantioselective Michael addition of a beta-ketoamide to an a, alpha,beta-unsaturated aldehyde, catalyzed by a secondary amine catalyst, and is followed by hemiaminal annulation. Optically enantiopure compounds with three stereogenic centres are obtained in good yields and excellent selectivities (up to > 20:1 dr and up to > 99 % ee).
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry

Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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