Eu(III) Complex with DO3A-amino-phosphonate Ligand as a Concentration-Independent pH-Responsive Contrast Agent for Magnetic Resonance Spectroscopy (MRS)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F17%3A10360069" target="_blank" >RIV/00216208:11310/17:10360069 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/17:00060342

Result on the web

<a href="http://dx.doi.org/10.1021/acs.inorgchem.6b02749" target="_blank" >http://dx.doi.org/10.1021/acs.inorgchem.6b02749</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.inorgchem.6b02749" target="_blank" >10.1021/acs.inorgchem.6b02749</a>

Result language

angličtina

Original language name

Eu(III) Complex with DO3A-amino-phosphonate Ligand as a Concentration-Independent pH-Responsive Contrast Agent for Magnetic Resonance Spectroscopy (MRS)

Original language description

A new DOTA-like ligand H5do3aNP with a 2-[amino(methylphosphonic acid)]ethyl-coordinating pendant arm was prepared, and its coordinating properties were studied by NMR spectroscopy and potentiometry. The study revealed a rare slow exchange (on the H-1 and P-31 NMR time scale) between protonated and unprotonated complex species with a corresponding acidity constant pK(A) similar to 8.0. This unusually slow time scale associated with protonation is caused by a significant geometric change from square-antiprismatic (SA) arrangement observed for protonated complex SA-[Eu(Hdo(3)aNP)]- to twisted-square-antiprismatic (TSA) arrangement found for deprotonated complex TSA-[Eu(do(3)aNP)](2). This behavior results in simultaneous occurrence of the signals of both species in the 31P NMR spectra at approximately -118 and +70 ppm, respectively. Such an unprecedented difference in the chemical shifts between species differing by a proton is caused by a significant movement of the principal magnetic axis and by a change of phosphorus atom position in the coordination sphere of the central Eu(III) ion (i.e., by relative movement of the phosphorus atom with respect to the principal magnetic axis). It changes the sign of the paramagnetic contribution to the 31P NMR chemical shift. The properties discovered can be employed in the measurement of pH by MRS techniques as presented by proof-of-principle experiments on phantoms.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10402 - Inorganic and nuclear chemistry

Project

<a href="/en/project/GA16-03156S" target="_blank" >GA16-03156S: Self-assembled polymeric nanostructures as bimodal magnetic resonance ultrasound contrast agents for imaging</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Inorganic Chemistry

ISSN

0020-1669

e-ISSN

—

Volume of the periodical

56

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

14

Pages from-to

2078-2091

UT code for WoS article

000394736600035

EID of the result in the Scopus database

2-s2.0-85013230695