Enantiomeric Separation of (R,S)-Aclidinium Bromide with Negatively Charged Gamma-Cyclodextrin by CE
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F17%3A10360820" target="_blank" >RIV/00216208:11310/17:10360820 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1007/s10337-017-3244-z" target="_blank" >https://doi.org/10.1007/s10337-017-3244-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10337-017-3244-z" target="_blank" >10.1007/s10337-017-3244-z</a>
Alternative languages
Result language
angličtina
Original language name
Enantiomeric Separation of (R,S)-Aclidinium Bromide with Negatively Charged Gamma-Cyclodextrin by CE
Original language description
A new CE method for separation of (R,S)-aclidinium bromide enantiomers has been developed and validated. In this method, sulphated gamma-CD 4.8% (w/v) in acidic background electrolyte based on potassium dihydrogen phosphate (100 mM, pH = 3.0) buffer was used for the determination in an uncoated fused silica capillary with extended capillary light path. The effect on the resolution of the chiral selector concentration, of the pH of the background electrolyte and also of other parameters was studied. (R)-Aclidinium bromide has therapeutic properties and, thus, a screening method is required for determination of low concentrations of (S)-aclidinium bromide as an optical impurity. The proposed method enables determination of 0.4% (S)-aclidinium bromide as an optical impurity in a synthetic laboratory sample.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chromatographia
ISSN
0009-5893
e-ISSN
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Volume of the periodical
80
Issue of the periodical within the volume
4
Country of publishing house
DE - GERMANY
Number of pages
5
Pages from-to
559-563
UT code for WoS article
000399024500006
EID of the result in the Scopus database
2-s2.0-85009865569