Enantiomeric separation of tapentadol by capillary electrophoresis-Study of chiral selectivity manipulation by various types of cyclodextrins

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33156326" target="_blank" >RIV/61989592:15310/15:33156326 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0731708514005548" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0731708514005548</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jpba.2014.11.027" target="_blank" >10.1016/j.jpba.2014.11.027</a>

Result language
angličtina
Original language name
Enantiomeric separation of tapentadol by capillary electrophoresis-Study of chiral selectivity manipulation by various types of cyclodextrins
Original language description
The chiral recognition of the centrally acting analgesic agent tapentadol and its isomers with various cyclodextrins (CDs) was studied by capillary electrophoresis, focusing on the migration order of four stereoisomers. In the case of non-charged hydroxypropylated CDs (2-hydroxypropyl-beta-CD, 2-hydroxypropyl-gamma-CD) the beta derivative was able to discriminate the S,R- and R,S-isomers in acidic background electrolyte, whereas the gamma allowed the separation of S,S- and R,R-tapentadol, respectively.Dual CD system containing both hosts was used to separate all of four isomers. Negatively charged sulfated-alpha-CD at 1.0% (w/v) concentration in 100 mM sodium borate buffer (pH 9.5) was capable of separating the isomers with favorable enantiomer migration order and the optimized method was able to determine 0.15% of chiral impurities of tapentadol in the presence of the last migrating clinically important R,R-isomer
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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