Characterization of a single-isomer carboxymethyl-beta-cyclodextrin in chiral capillary electrophoresis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F17%3A10370969" target="_blank" >RIV/00216208:11310/17:10370969 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1002/elps.201700004" target="_blank" >http://dx.doi.org/10.1002/elps.201700004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/elps.201700004" target="_blank" >10.1002/elps.201700004</a>

Result language

angličtina

Original language name

Characterization of a single-isomer carboxymethyl-beta-cyclodextrin in chiral capillary electrophoresis

Original language description

In this work, the synthesis, characterization, and chiral capillary electrophoretic study of heptakis-(2,3-di-O-methyl-6-O-carboxymethyl)-beta-CD (HDMCM), a single-isomer carboxymethylated CD, are presented. The pH-dependent and selector concentration-dependent enantiorecognition properties of HDMCM were investigated and discussed herein. The enantioseparation was assessed applying a structurally diverse set of non-charged, basic, and zwitterionic racemates. The increase in the selector concentration and gross negative charge of HDMCM improved the enantioseparation that could be observed in the majority of the cases. HDMCM was also successfully applied as BGE additive in NACE using a methanol-based system in order to prove the separation selectivity features and to highlight the broad applicability of HDMCM. Over 25 racemates showed partial or baseline separation with HDMCM under the conditions investigated, among which optimal enantiomer migration order was found for the four stereoisomers of tadalafil, tapentadol, and dapoxetine, offering the possibility of a chiral CE method development for chiral purity profiling of these drugs.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10401 - Organic chemistry

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Electrophoresis

ISSN

0173-0835

e-ISSN

—

Volume of the periodical

38

Issue of the periodical within the volume

15

Country of publishing house

DE - GERMANY

Number of pages

9

Pages from-to

1869-1877

UT code for WoS article

000406724200007

EID of the result in the Scopus database

2-s2.0-85019203361