The influence of substituent position in monocarboxymethyl-gamma-cyclodextrins on enantioselectivity in capillary electrophoresis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F14%3A43897172" target="_blank" >RIV/60461373:22340/14:43897172 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/jssc.201400604" target="_blank" >http://dx.doi.org/10.1002/jssc.201400604</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jssc.201400604" target="_blank" >10.1002/jssc.201400604</a>
Alternative languages
Result language
angličtina
Original language name
The influence of substituent position in monocarboxymethyl-gamma-cyclodextrins on enantioselectivity in capillary electrophoresis
Original language description
Three newly synthesized chiral selectors, namely, 2I-O-, 3I-O-, and 6I-O-carboxymethyl-?-cyclodextrin, native ?-cyclodextrin, and commercially available carboxymethylated ?-cyclodextrin with degree of substitution of 3-6 were used as additives in a background electrolyte composed of phosphate buffer at 20 mmol/L concentration and pH 2.5. This systém was used for the analysis of several biologically significant low-molecular-mass chiral compounds by capillary electrophoresis. The results confirmed that the position of carboxymethyl group influences the enantioseparation efficiency of all the studied analytes. The 2I-O- and 3I-O- regioisomers provide a significantly better resolution than native ?-cyclodextrin, while the 6I-O-regioisomer gives only a slightly better enantioseparation than native ?-cyclodextrin. The application of ?-cyclodextrin possessing higher number of carboxymethyl groups led to the best resolution for the majority of the compounds analyzed.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP206%2F12%2F0453" target="_blank" >GAP206/12/0453: Affinity capillary electromigration methods for selective nanoanalysis of biomolecules and investigation of their interactions</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Separation Sciences online
ISSN
1615-9314
e-ISSN
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Volume of the periodical
37
Issue of the periodical within the volume
19
Country of publishing house
DE - GERMANY
Number of pages
6
Pages from-to
2779-2784
UT code for WoS article
000342909300020
EID of the result in the Scopus database
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