The influence of the substituent position in monocarboxymethyl-gamma-cyclodextrins on enantioselectivity in capillary electrophoresis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10282374" target="_blank" >RIV/00216208:11310/14:10282374 - isvavai.cz</a>

Alternative codes found

RIV/46747885:24620/14:#0000456

Result on the web

<a href="http://dx.doi.org/10.1002/jssc.201400604" target="_blank" >http://dx.doi.org/10.1002/jssc.201400604</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jssc.201400604" target="_blank" >10.1002/jssc.201400604</a>

Result language

angličtina

Original language name

The influence of the substituent position in monocarboxymethyl-gamma-cyclodextrins on enantioselectivity in capillary electrophoresis

Original language description

Three newly synthesized chiral selectors, namely, 2(I)-O-, 3(I)-O-, and 6(I)-O-carboxymethyl--cyclodextrin, native -cyclodextrin, and commercially available carboxymethylated -cyclodextrin with degree of substitution of 3-6 were used as additives in a background electrolyte composed of phosphate buffer at 20mmol/L concentration and pH 2.5. This system was used for the analysis of several biologically significant low-molecular-mass chiral compounds by capillary electrophoresis. The results confirmed thatthe position of carboxymethyl group influences the enantioseparation efficiency of all the studied analytes. The 2(I)-O- and 3(I)-O- regioisomers provide a significantly better resolution than native -cyclodextrin, while the 6(I)-O-regioisomer gives only a slightly better enantioseparation than native -cyclodextrin. The application of -cyclodextrin possessing higher number of carboxymethyl groups led to the best resolution for the majority of the compounds analyzed.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Separation Science

ISSN

1615-9306

e-ISSN

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Volume of the periodical

37

Issue of the periodical within the volume

19

Country of publishing house

DE - GERMANY

Number of pages

6

Pages from-to

2779-2784

UT code for WoS article

000342909300020

EID of the result in the Scopus database

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