HILIC-MS/MS Method for Analysis of Ephedrine in Internet-available Drugs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F17%3A10362609" target="_blank" >RIV/00216208:11310/17:10362609 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1007/s10337-016-3170-5" target="_blank" >https://doi.org/10.1007/s10337-016-3170-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10337-016-3170-5" target="_blank" >10.1007/s10337-016-3170-5</a>
Alternative languages
Result language
angličtina
Original language name
HILIC-MS/MS Method for Analysis of Ephedrine in Internet-available Drugs
Original language description
A new separation method involving hydrophilic interaction liquid chromatography with tandem mass spectrometric detection has been developed for the analysis of ephedrine in a pharmaceutical solid dosage form. The optimized conditions for the analysis of ephedrine consisted of an Acquity BEH Amide column, and a mobile phase composed of acetonitrile/5 mM ammonium formate, pH 3.0, 88/12 (v/v), flow rate 0.4 mL min(-1) and column temperature 30 A degrees C. The developed analytical procedure provides high throughput of samples where LC analysis takes only 90 s. Detection was performed by tandem mass spectrometry using electrospray ionization in multiple reaction monitoring mode. This method was found to be precise, linear, accurate, sensitive, selective and robust for routine application in screening of commercial pharmaceutical products based on the content of ephedrine. Application of the method for the determination of ephedrine content in 20 different pharmaceutical drug products revealed that 5 samples did not contain any ephedrine at all, 3 samples contained lower dosage than declared, and the dosage in 1 sample was exceeded.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chromatographia
ISSN
0009-5893
e-ISSN
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Volume of the periodical
80
Issue of the periodical within the volume
4
Country of publishing house
DE - GERMANY
Number of pages
6
Pages from-to
523-528
UT code for WoS article
000399024500002
EID of the result in the Scopus database
2-s2.0-84988568706