Amino acids amides of anti-influenza drugs: synthesis and biological activities
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F17%3A10367829" target="_blank" >RIV/00216208:11310/17:10367829 - isvavai.cz</a>
Result on the web
<a href="http://www.bcc.bas.bg/BCC_Volumes/Volume_49_Special_E_2017/BCC-49-E-2017-16-22-Stoykova-3.pdf" target="_blank" >http://www.bcc.bas.bg/BCC_Volumes/Volume_49_Special_E_2017/BCC-49-E-2017-16-22-Stoykova-3.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Amino acids amides of anti-influenza drugs: synthesis and biological activities
Original language description
Influenza A viruses are amongst the most severe human pathogens leading to high morbidity and mortality worldwide. Due to the high mutation rate and the unpredictable potential for influenza pandemic outbreaks, the development of novel anti-influenza drugs is an undeniably attractive area of research. In the present study amino acid amides of rimantadine and oseltamivir were synthesized and their in vitro antiviral activity against influenza A viruses (A/H3N2) was studied. Results revealed that amide modification of N-alpha- and side chain protected tyrosine, histidine, aspartic- and glutamic acids did not exhibit significant enhancement of the in vitro effect against influenza A virus strain.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bulgarian Chemical Communications
ISSN
0324-1130
e-ISSN
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Volume of the periodical
49
Issue of the periodical within the volume
Special Issue E
Country of publishing house
BG - BULGARIA
Number of pages
7
Pages from-to
16-22
UT code for WoS article
000418303600004
EID of the result in the Scopus database
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