Synthesis, characterization, DNA binding, topoisomerase I inhibition and antimicrobial activity of four novel zinc(II) fenamates
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F18%3A10374394" target="_blank" >RIV/00216208:11310/18:10374394 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.poly.2017.11.052" target="_blank" >https://doi.org/10.1016/j.poly.2017.11.052</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.poly.2017.11.052" target="_blank" >10.1016/j.poly.2017.11.052</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis, characterization, DNA binding, topoisomerase I inhibition and antimicrobial activity of four novel zinc(II) fenamates
Original language description
Four novel Zn(II) complexes containing fenamic acid (Hfen), a precursor of non-steroidal anti-inflammatory drugs (NSAIDs), and different coligands namely methanol, N,N,N',N'-tetramethylethylene diamine (tmen), N,N'-bis(3-aminopropyl)ethylenediamine (bapen) and 14,811-tetraazacyclotetradecane (cyclam) were prepared in crystalline form. The composition of the complexes was determined by infrared spectroscopy, elemental and thermal analyses. Results of single-crystal X-ray structure analysis have revealed that while complex 1 is composed of trinuclear [Zn-3(fen)(6)(MeOH)(2)] molecules, the three remaining complexes 2-4 are mononuclear with composition [Zn(fen)(2)(tmen)] (2), [Zn(bapen)(fen)]fen (3), and [Zn (cyclam)(fen)(2)] (4). Binding of all prepared complexes to calf thymus DNA was investigated using UV-vis, fluorescence and circular dichroism (CD) measurements. In addition, inhibition activity of complexes against topoisomerase I along with antimicrobial activity was determined.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Polyhedron
ISSN
0277-5387
e-ISSN
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Volume of the periodical
141
Issue of the periodical within the volume
February
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
230-238
UT code for WoS article
000424961200030
EID of the result in the Scopus database
2-s2.0-85038004060