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Synthesis, characterization, DNA binding, topoisomerase I inhibition and antimicrobial activity of four novel zinc(II) fenamates

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F18%3A10374394" target="_blank" >RIV/00216208:11310/18:10374394 - isvavai.cz</a>

  • Result on the web

    <a href="https://doi.org/10.1016/j.poly.2017.11.052" target="_blank" >https://doi.org/10.1016/j.poly.2017.11.052</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.poly.2017.11.052" target="_blank" >10.1016/j.poly.2017.11.052</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Synthesis, characterization, DNA binding, topoisomerase I inhibition and antimicrobial activity of four novel zinc(II) fenamates

  • Original language description

    Four novel Zn(II) complexes containing fenamic acid (Hfen), a precursor of non-steroidal anti-inflammatory drugs (NSAIDs), and different coligands namely methanol, N,N,N&apos;,N&apos;-tetramethylethylene diamine (tmen), N,N&apos;-bis(3-aminopropyl)ethylenediamine (bapen) and 14,811-tetraazacyclotetradecane (cyclam) were prepared in crystalline form. The composition of the complexes was determined by infrared spectroscopy, elemental and thermal analyses. Results of single-crystal X-ray structure analysis have revealed that while complex 1 is composed of trinuclear [Zn-3(fen)(6)(MeOH)(2)] molecules, the three remaining complexes 2-4 are mononuclear with composition [Zn(fen)(2)(tmen)] (2), [Zn(bapen)(fen)]fen (3), and [Zn (cyclam)(fen)(2)] (4). Binding of all prepared complexes to calf thymus DNA was investigated using UV-vis, fluorescence and circular dichroism (CD) measurements. In addition, inhibition activity of complexes against topoisomerase I along with antimicrobial activity was determined.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10402 - Inorganic and nuclear chemistry

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Polyhedron

  • ISSN

    0277-5387

  • e-ISSN

  • Volume of the periodical

    141

  • Issue of the periodical within the volume

    February

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    9

  • Pages from-to

    230-238

  • UT code for WoS article

    000424961200030

  • EID of the result in the Scopus database

    2-s2.0-85038004060