Novel Zn(II) complexes with non-steroidal anti-inflammatory ligand, flufenamic acid: Characterization, topoisomerase I inhibition activity, DNA and HSA binding studies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F17%3A10370129" target="_blank" >RIV/00216208:11310/17:10370129 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1016/j.jinorgbio.2017.09.005" target="_blank" >https://doi.org/10.1016/j.jinorgbio.2017.09.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jinorgbio.2017.09.005" target="_blank" >10.1016/j.jinorgbio.2017.09.005</a>

Result language

angličtina

Original language name

Novel Zn(II) complexes with non-steroidal anti-inflammatory ligand, flufenamic acid: Characterization, topoisomerase I inhibition activity, DNA and HSA binding studies

Original language description

A series of new Zn(II) complexes with flufenamic acid (flu) has been synthesized, namely [Zn3(drnso)2(flu)61 (1), [Zn-3(flu)(6)(py)(2)] (2), (Zn(flu)(2)(tnien)] (3), [ZnCl(fiu)(neo)] (4), and [Zn(cyciam)(flu)(2)] (5), where py = pyridine, tmen = N,N,N&apos;,N&apos;-Tetramethylethylene diamine, neo = 2,9-Dimethyl-1,10-phenanthroline and cyclam = 1,4,8,11-Tetraazacyclotetradecane. These complexes have been characterized by infrared spectroscopy, single-crystal X-ray structure analysis, elemental and thermal analysis. All complexes contain deprotonated flufenamic acid coordinated via carboxylato group to zinc atoms, but their structures differ in the carboxylato binding mode, the coordination number of the central atom, the shape of the coordination polyhedra and the resultant supramolecular structures. Furthermore, an interaction of complexes with calf-thymus DNA (CT DNA) and human serum albumin (HSA) has been investigated by spectroscopic techniques. Moreover, the complexes 1 and 2 inhibit the catalytic activity of topoisomerase I at 60 mu M.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10402 - Inorganic and nuclear chemistry

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Inorganic Biochemistry

ISSN

0162-0134

e-ISSN

—

Volume of the periodical

177

Issue of the periodical within the volume

December

Country of publishing house

US - UNITED STATES

Number of pages

16

Pages from-to

143-158

UT code for WoS article

000419812400016

EID of the result in the Scopus database

2-s2.0-85029920077