Vanillylmandelic and Homovanillic acid: Electroanalysis at non-modified and polymer-modified carbon-based electrodes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F18%3A10376694" target="_blank" >RIV/00216208:11310/18:10376694 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.jelechem.2018.03.011" target="_blank" >https://doi.org/10.1016/j.jelechem.2018.03.011</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jelechem.2018.03.011" target="_blank" >10.1016/j.jelechem.2018.03.011</a>
Alternative languages
Result language
angličtina
Original language name
Vanillylmandelic and Homovanillic acid: Electroanalysis at non-modified and polymer-modified carbon-based electrodes
Original language description
The electrochemical behaviour of two main catecholamine metabolites serving as diagnostic tumour biomarkers, homovanillic acid (HVA) and vanillylmandelic acid (VMA), on anodically oxidized boron doped diamond (BDD) electrodes, non-modified glassy carbon electrodes (GCE), and GCE modified by polymers, namely by Nafion (Nafion/GCE) and by poly(neutral red) (PNR/GCE), was investigated. The voltammetric responses of both biomarkers are strongly dependent on pH of the aqueous buffer solution and electrode material used. BDD electrodes exhibit more positive oxidation potentials and lower current densities for oxidation of both analytes, depending also on the surface termination. Concentration dependences were measured in 0.1 mol L-1 phosphate buffer pH 3.0, as optimal supporting electrolyte for differential pulse voltammetric determination. Achieved detection limits were 0.6, 0.9, 0.8, and 1.2 mu mol L-1 for HVA and 0.4, 1.5, 2.4, and 1.1 mu mol L-1 for VMA at BDD electrodes, non-modified GCE, Nafion/GCE, and PNR/GCE, respectively. The limits of quantification for both organic compounds on all tested electrode materials are sufficiently low for their determination in urine. Verification of the possibility of simultaneous voltammetric determination of the studied biomarkers in the mixture was also carried out.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
<a href="/en/project/GA15-02815S" target="_blank" >GA15-02815S: New recognition principles and approaches to electrochemical detection of tumor markers</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Electroanalytical Chemistry
ISSN
1572-6657
e-ISSN
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Volume of the periodical
821
Issue of the periodical within the volume
July
Country of publishing house
CH - SWITZERLAND
Number of pages
11
Pages from-to
22-32
UT code for WoS article
000437818600005
EID of the result in the Scopus database
2-s2.0-85043496850