Lanthanide(III) complexes of monophosphinate/monophosphonate DOTA-analogues: Effects of the substituents on the formation rate and radiolabelling yield
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F18%3A10381829" target="_blank" >RIV/00216208:11310/18:10381829 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1039/c8dt02608d" target="_blank" >https://doi.org/10.1039/c8dt02608d</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c8dt02608d" target="_blank" >10.1039/c8dt02608d</a>
Alternative languages
Result language
angličtina
Original language name
Lanthanide(III) complexes of monophosphinate/monophosphonate DOTA-analogues: Effects of the substituents on the formation rate and radiolabelling yield
Original language description
H4dota and its analogues are routinely used for complexation of lanthanide radioisotopes in nuclear medicine. Many of the radioisotopes have short half-lives and, thus, the complexation rate plays an important role. Notwithstanding that, the relationship between ligand structures and complexation rates is not well understood. Here we report a complexation study of H(4)dota and its analogues bearing one phosphonate or phosphinate pendant arm. The substituents on the phosphinate group were non-coordinating (-H) or contained another coordinating group (-CH2N(CH2COOH)(2), -CH2PO2H2 or -CH2NH2). The basicity of ligands, stability of reaction intermediates, formation rates of Ce-III complexes, and Lu-177(III) radiolabelling were studied. The complexation rates and labelling yields do not show any correlation with ligand basicity. In contrast, the additional chelating group attached to the pendant arm plays an important role. A decreased complexation rate and lower labelling yield were found for compounds bearing an additional amino group, whereas improved properties were found for the compound bearing a geminal bis(phosphinate) pendant arm. It indicates that the introduction of chelating pendant arms with acidic coordinating groups might be a promising strategy to improve radiolabelling of macrocyclic carriers with metal radioisotopes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
<a href="/en/project/LTC17067" target="_blank" >LTC17067: Application of NMR relaxation and diffusion measurements to assess dynamics of complex molecular systems</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Dalton Transactions
ISSN
1477-9226
e-ISSN
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Volume of the periodical
47
Issue of the periodical within the volume
37
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
13006-13015
UT code for WoS article
000445637000025
EID of the result in the Scopus database
2-s2.0-85054388740