A UV-Vis method for investigation of gallium(III) complexation kinetics with NOTA and TRAP chelators: advantages, limitations and comparison with radiolabelling
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F24%3A10490649" target="_blank" >RIV/00216208:11310/24:10490649 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Hqst-kVpc_" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Hqst-kVpc_</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d4dt02383h" target="_blank" >10.1039/d4dt02383h</a>
Alternative languages
Result language
angličtina
Original language name
A UV-Vis method for investigation of gallium(III) complexation kinetics with NOTA and TRAP chelators: advantages, limitations and comparison with radiolabelling
Original language description
An easy and cheap method for measurement of Ga(III) complexation kinetics was developed. The method is based on UV-Vis quantification of non-complexed chelators after the addition of Cu(II) ions at individual time points. The method was evaluated using established ligands, H(3)nota and H(6)notP(Pr), and was utilized to study the kinetics of Ga-III complexation with four new symmetric derivatives of 1,4,7-triazacyclononane bearing methylphosphonate/phosphinate pendant arms - TRAP ligands. Chelators bearing ethoxy groups (H(3)L1) or 2,2,2-trifluoroethyl groups (H(3)L2) on the phosphorus atoms showed fast formation (t(99%) = 21 and 10 min, respectively, at pH 2.0) and efficient radiolabelling which were comparable to the previously reported chelators bearing the 2-carboxyethyl group (H(6)notP(Pr)). Chelators bearing (N,N-dibenzyl-amino)methyl (H(3)L3) and aminomethyl (H(3)L4) substituents showed a significantly slower complexation (t(99%) = 4.4 and 3.6 h, respectively, at pH 2.0) and inefficient radiolabelling, mainly at room temperature or low pH. This was caused by protonation of the amino groups of the pendant arms leading to coulombic repulsion between the Ga(III) ion and the positively charged protonated amines. The trends in complexation rates determined by the UV-Vis method correlated well with the results of the Ga-68 radiolabelling study.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
<a href="/en/project/TH78020003" target="_blank" >TH78020003: Imaging and Inhibitor Probe for Alzheimer's Disease Diagnostic and Treatment</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Dalton Transactions
ISSN
1477-9226
e-ISSN
1477-9234
Volume of the periodical
53
Issue of the periodical within the volume
43
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
17554-17564
UT code for WoS article
001337005800001
EID of the result in the Scopus database
2-s2.0-85206602870