Spectroscopic Characterization of New Eu(III)/DOTA Analogue Complexes as potential MRI Agents
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F03%3A00009628" target="_blank" >RIV/00216224:14310/03:00009628 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/03:00008746
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Spectroscopic Characterization of New Eu(III)/DOTA Analogue Complexes as potential MRI Agents
Original language description
Ln(III) complexes of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate) and their analogues are used for their high thermodynamic stability, kinetic inertness and other properties as MRI or luminescent probes in medicine. New analogues of DOTA were prepared by substitution of one acetic group by pendant groups containing phosphonic group. The formation kinetics between Eu(III) and recently synthesized ligands were studied under experimental conditions (t = 25 oC, I = 0.1 mol.l-1, pH = 4-6) by means of UV/VIS absorption spectroscopy and two steps were observed: Eu3+ + HxL <=> (x-y)H+ + Eu(HyL) --> Eu(L) + yH+ The first step - the coordination of Eu(III) ion by pendant groups is very fast. In the second step, the transformation of an intermediate to the final complex in which Eu(III) ion is coordinated by four pendant groups and four nitrogen donor atoms of the cyclen ring, takes place. This step is very slow and it is proportional to OH- ion concentration. The estimates of prot
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Abstract Book of Conference "TOWARDS MOLECULAR ELECTRONICS" (Central European Conference on Advanced Materials and Nanotechnology), Srem, Poland, June 23-28, 2003.
ISBN
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ISSN
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e-ISSN
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Number of pages
1
Pages from-to
105
Publisher name
Adam Mickiewicz University
Place of publication
Poznan
Event location
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Event date
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Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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