Decarboxylative Organocatalytic Allylic Amination of Morita-Baylis-Hillman Carbamates

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F18%3A10383127" target="_blank" >RIV/00216208:11310/18:10383127 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/18:00494023
Result on the web
<a href="https://doi.org/10.1002/chem.201803677" target="_blank" >https://doi.org/10.1002/chem.201803677</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/chem.201803677" target="_blank" >10.1002/chem.201803677</a>

Result language
angličtina
Original language name
Decarboxylative Organocatalytic Allylic Amination of Morita-Baylis-Hillman Carbamates
Original language description
The present study reports the organocatalytic enantioselective allylic amination of Morita-Baylis-Hillman carbamates efficiently catalyzed by a chiral amine in the presence of a Bronsted acid. Chiral allylic amines were produced in high yields (up to 98%) and enantioselectivities (up to 97% ee). This method provides an efficient and easily performed route to prepare alpha-methylene beta-lactams, and other optically active beta-lactams, such as the cholesterol-lowering drug Ezetimibe.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10401 - Organic chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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