Changes in the activity of some metabolic enzymes in the heart of SHR rat incurred by transgenic expression of CD36
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F18%3A10387200" target="_blank" >RIV/00216208:11310/18:10387200 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/18:00493613
Result on the web
<a href="https://doi.org/10.1007/s13105-018-0641-1" target="_blank" >https://doi.org/10.1007/s13105-018-0641-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13105-018-0641-1" target="_blank" >10.1007/s13105-018-0641-1</a>
Alternative languages
Result language
angličtina
Original language name
Changes in the activity of some metabolic enzymes in the heart of SHR rat incurred by transgenic expression of CD36
Original language description
Hypertension, dyslipidemia, and insulin resistance in the spontaneously hypertensive rat (SHR) can be alleviated by rescuing CD36 fatty acid translocase. The present study investigated whether transgenic rescue of CD36 in SHR could affect mitochondrial function and activity of selected metabolic enzymes in the heart. These analyses were conducted on ventricular preparations derived from SHR and from transgenic strain SHR-Cd36 that expresses a functional wild-type CD36. Our respirometric measurements revealed that mitochondria isolated from the left ventricles exhibited two times higher respiratory activity than those isolated from the right ventricles. Whereas, we did not observe any significant changes in functioning of the mitochondrial respiratory system between both rat strains, enzyme activities of total hexokinase, and both mitochondrial and total malate dehydrogenase were markedly decreased in the left ventricles of transgenic rats, compared to SHR. We also detected downregulated expression of the succinate dehydrogenase subunit SdhB (complex II) and 70 kDa peroxisomal membrane protein in the left ventricles of SHR-Cd36. These data indicate that CD36 may affect in a unique fashion metabolic substrate flexibility of the left and right ventricles.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
<a href="/en/project/GB14-36804G" target="_blank" >GB14-36804G: Centre of mitochondrial biology and pathology (MITOCENTRE)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Physiology and Biochemistry
ISSN
1138-7548
e-ISSN
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Volume of the periodical
74
Issue of the periodical within the volume
3
Country of publishing house
ES - SPAIN
Number of pages
11
Pages from-to
479-489
UT code for WoS article
000440827500011
EID of the result in the Scopus database
2-s2.0-85048690725