Pharmacogenetic evidence that cd36 is a key determinant of the metabolic effects of pioglitazone.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F02%3A20020105" target="_blank" >RIV/67985823:_____/02:20020105 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/02:00002342 RIV/00023001:_____/02:00000030
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Pharmacogenetic evidence that cd36 is a key determinant of the metabolic effects of pioglitazone.
Original language description
295 To specifically investigate the role of the Cd36 fatty acid transporter gene in the insulin sensitizing actions of thiazolidinediones, we studied the metabolic effects of pioglitazone in spontaneously hypertensive rats (SHR) that harbor a deletion mutation in Cd36 in comparison to congenic and transgenic strains of SHR that express wild type Cd36. Our findings provide direct pharmacogenetic evidence that in the SHR model, Cd36 is a key determinant of the insulin sensitizing actions of a thiazolidinedione ligand of PPAR?.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Biological Chemistry
ISSN
0021-9258
e-ISSN
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Volume of the periodical
277
Issue of the periodical within the volume
50
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
48501-48507
UT code for WoS article
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EID of the result in the Scopus database
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