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Pharmacogenetic evidence that cd36 is a key determinant of the metabolic effects of pioglitazone.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F02%3A20020105" target="_blank" >RIV/67985823:_____/02:20020105 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/02:00002342 RIV/00023001:_____/02:00000030

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Pharmacogenetic evidence that cd36 is a key determinant of the metabolic effects of pioglitazone.

  • Original language description

    295 To specifically investigate the role of the Cd36 fatty acid transporter gene in the insulin sensitizing actions of thiazolidinediones, we studied the metabolic effects of pioglitazone in spontaneously hypertensive rats (SHR) that harbor a deletion mutation in Cd36 in comparison to congenic and transgenic strains of SHR that express wild type Cd36. Our findings provide direct pharmacogenetic evidence that in the SHR model, Cd36 is a key determinant of the insulin sensitizing actions of a thiazolidinedione ligand of PPAR?.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2002

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Biological Chemistry

  • ISSN

    0021-9258

  • e-ISSN

  • Volume of the periodical

    277

  • Issue of the periodical within the volume

    50

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

    48501-48507

  • UT code for WoS article

  • EID of the result in the Scopus database