Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F01%3A20010171" target="_blank" >RIV/67985823:_____/01:20010171 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats.

Original language description

We found that in SHR harboring the deletion variant of Cd36 (fatty acid transporter), transgenic expression of wild type Cd36 in modest amounts ameliorates defects in fatty acid metabolism, glucose tolerance, and insulin stimulated glucose uptake in muscle and fat tissue and second, exerts little or no effect on blood pressure. In conclusion, the current studies provide definitive evidence that mutant Cd36 is a QTL with major effect on insulin action, glucose tolerance, and serum fatty acid levels in the SHR/NIH strains.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature Genetics

ISSN

1061-4036

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

3

Pages from-to

156-158

UT code for WoS article

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EID of the result in the Scopus database

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