Formal [3+2] cycloaddition of vinylcyclopropane azlactones to enals using synergistic catalysis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F19%3A10394011" target="_blank" >RIV/00216208:11310/19:10394011 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=WCjqiyIv7W" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=WCjqiyIv7W</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c8cc06500d" target="_blank" >10.1039/c8cc06500d</a>

Result language
angličtina
Original language name
Formal [3+2] cycloaddition of vinylcyclopropane azlactones to enals using synergistic catalysis
Original language description
The present study reports the asymmetric cyclization of enals with vinylcyclopropane azlactones efficiently catalyzed by the combination of achiral Pd(0) complexes and chiral secondary amines. Corresponding spirocyclic azlactones were produced in high yields with moderate diastereoselectivities and excellent enantioselectivities. This protocol provides an efficient and easily-performed route to spirocyclic scaffolds, and densely functionalized cyclopentanes containing quaternary carbon centers.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10401 - Organic chemistry

Project
<a href="/en/project/GA18-20645S" target="_blank" >GA18-20645S: Combined organo- and metal catalysis (CORMECA)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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