Degradation of the opium alkaloids in pharmaceutical relics from the 18th century
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F19%3A10397349" target="_blank" >RIV/00216208:11310/19:10397349 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=j1FL1lO5ie" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=j1FL1lO5ie</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00706-019-02461-z" target="_blank" >10.1007/s00706-019-02461-z</a>
Alternative languages
Result language
angličtina
Original language name
Degradation of the opium alkaloids in pharmaceutical relics from the 18th century
Original language description
The opium alkaloids in three historical pharmaceutical relics dated to the eighteenth century were analyzed by HPLC-MS. The conditions of extraction of alkaloids from the sample and their HPLC analysis were optimized. A broad spectrum of opium alkaloids was found and degradation products of papaverine and noscapine were identified. The identity of compounds found was confirmed by MS/MS. For three compounds (methylhydrocotarnine, papaverinol, and papaveraldine) the ESI+-MS/MS fragmentation mechanism has been proposed. The content of five selected opium alkaloids (cotarnine, meconin, morphine, papaverine, and noscapine) was determined in analyzed samples, and the concentration ratio of noscapine and cotarnine was proposed as a marker of the age of a preparation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Monatshefte für Chemie - Chemical Monthly
ISSN
0026-9247
e-ISSN
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Volume of the periodical
150
Issue of the periodical within the volume
9
Country of publishing house
AT - AUSTRIA
Number of pages
10
Pages from-to
1593-1602
UT code for WoS article
000482907600007
EID of the result in the Scopus database
2-s2.0-85070205786