HPLC-MS analysis of ipecacuanha alkaloids in pharmaceutical relics from eighteenth century

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F18%3A10381601" target="_blank" >RIV/00216208:11310/18:10381601 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1007/s00706-018-2223-x" target="_blank" >https://doi.org/10.1007/s00706-018-2223-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00706-018-2223-x" target="_blank" >10.1007/s00706-018-2223-x</a>

Result language
angličtina
Original language name
HPLC-MS analysis of ipecacuanha alkaloids in pharmaceutical relics from eighteenth century
Original language description
The alkaloids in two historical pharmaceutical relics of ipecacuanha, dated to the eighteenth century, were analyzed by HPLC-MS. The conditions of extraction and separation were optimized. Four alkaloids (emetine, cephaeline, protoemetine, and O-methylpsychotrine) were found. The content of the main ipecacuanha alkaloids, emetine and cephaeline, in analyzed samples is fairly decreased in comparison with standard current pharmaceutical substance. O-Methylpsychotrine has been identified as the emetine decomposition product. The identity of the compounds was confirmed by MS2, and the ESI+ fragmentation mechanisms of compounds found have been proposed.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry

Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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