Voltammetric study of triazole antifungal agent terconazole on sp(3) and sp(2) carbon-based electrode materials
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F20%3A10410708" target="_blank" >RIV/00216208:11310/20:10410708 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=uz3niTJ~FR" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=uz3niTJ~FR</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jelechem.2020.114054" target="_blank" >10.1016/j.jelechem.2020.114054</a>
Alternative languages
Result language
angličtina
Original language name
Voltammetric study of triazole antifungal agent terconazole on sp(3) and sp(2) carbon-based electrode materials
Original language description
Terconazole belongs to synthetic triazole antifungal agents, inhibiting biosynthesis of ergosterol or other sterols and thus disrupting cell wall synthesis in fungi. In this study, electrochemical behavior of terconazole was studied for the first time using cyclic voltammetry and differential pulse voltammetry on boron doped diamond electrode (BDD) with different surface treatments leading to O-terminated, H-terminated and polished surfaces, as well as on glassy carbon (GCE) and basal-plane pyrolytic graphite electrodes (PGE). Terconazole is not reducible within the potential window on these electrode materials. It is oxidizable in aqueous solutions in pH range from 2.0 to 12.0 in two steps due to the presence of piperazine ring in itsmolecule, possessing two redox centers at the tertiary nitrogen atoms, by an ECE mechanism. Optimal conditions were found for determination of terconazole in 0.1 mol L-1 phosphate buffer pH 7.2. Using differential pulse voltammetry, the lowest detection limit of 0.40 mu mol L-1 and excellent repeatability (RSD 1.1%) were achieved on O-terminated BDD when in-situ anodic activation was used prior to each scan. This is beneficial in comparison with GCE and PGE; their necessity of ex-situ polishing worsens the signal repeatability (RSD similar to 4%) and detection limits reaching 0.50 mu mol L-1 and 1.23 mu mol L-1, respectively.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
<a href="/en/project/GA18-01710S" target="_blank" >GA18-01710S: GROUP INTERACTIONS OF AZOLE PESTICIDES AND THEIR EFFECTS ON ESSENTIAL ENZYMES</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Electroanalytical Chemistry
ISSN
1572-6657
e-ISSN
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Volume of the periodical
863
Issue of the periodical within the volume
April
Country of publishing house
CH - SWITZERLAND
Number of pages
10
Pages from-to
114054
UT code for WoS article
000525909600012
EID of the result in the Scopus database
2-s2.0-85081932491