Lineage analysis reveals an endodermal contribution to the vertebrate pituitary
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F20%3A10417567" target="_blank" >RIV/00216208:11310/20:10417567 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=NJ9WW7Ie7p" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=NJ9WW7Ie7p</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/science.aba4767" target="_blank" >10.1126/science.aba4767</a>
Alternative languages
Result language
angličtina
Original language name
Lineage analysis reveals an endodermal contribution to the vertebrate pituitary
Original language description
Vertebrate sensory organs arise from epithelial thickenings called placodes. Along with neural crest cells, cranial placodes are considered ectodermal novelties that drove evolution of the vertebrate head. The anterior-most placode generates the endocrine lobe [adenohypophysis (ADH)] of the pituitary, a master gland controlling growth, metabolism, and reproduction. In addition to known ectodermal contributions, we use lineage tracing and time-lapse imaging in zebrafish to identify an endodermal contribution to the ADH. Single-cell RNA sequencing of the adult pituitary reveals similar competency of endodermal and ectodermal epithelia to generate all endocrine cell types. Further, endoderm can generate a rudimentary ADH-like structure in the near absence of ectodermal contributions. The fish condition supports the vertebrate pituitary arising through interactions of an ancestral endodermderived proto-pituitary with newly evolved placodal ectoderm.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10613 - Zoology
Result continuities
Project
<a href="/en/project/GA19-18634S" target="_blank" >GA19-18634S: Craniofacial development of non-teleost fishes as a unique model of the vertebrate head evolution</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science
ISSN
0036-8075
e-ISSN
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Volume of the periodical
370
Issue of the periodical within the volume
6515
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
463-466
UT code for WoS article
000581077200046
EID of the result in the Scopus database
2-s2.0-85094562681