The Role of Lipid Environment in Ganglioside GM1-Induced Amyloid beta Aggregation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F20%3A10422951" target="_blank" >RIV/00216208:11310/20:10422951 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=aMAFXwSgnC" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=aMAFXwSgnC</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/membranes10090226" target="_blank" >10.3390/membranes10090226</a>
Alternative languages
Result language
angličtina
Original language name
The Role of Lipid Environment in Ganglioside GM1-Induced Amyloid beta Aggregation
Original language description
Ganglioside GM1 is the most common brain ganglioside enriched in plasma membrane regions known as lipid rafts or membrane microdomains. GM1 participates in many modulatory and communication functions associated with the development, differentiation, and protection of neuronal tissue. It has, however, been demonstrated that GM1 plays a negative role in the pathophysiology of Alzheimer's disease (AD). The two features of AD are the formation of intracellular neurofibrillary bodies and the accumulation of extracellular amyloid beta (A beta). A beta is a peptide characterized by intrinsic conformational flexibility. Depending on its partners, A beta can adopt different spatial arrangements. GM1 has been shown to induce specific changes in the spatial organization of A beta, which lead to enhanced peptide accumulation and deleterious effect especially on neuronal membranes containing clusters of this ganglioside. Changes in GM1 levels and distribution during the development of AD may contribute to the aggravation of the disease.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Membranes
ISSN
2077-0375
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
9
Country of publishing house
CH - SWITZERLAND
Number of pages
22
Pages from-to
226
UT code for WoS article
000581377300001
EID of the result in the Scopus database
2-s2.0-85090395924