Impact of GM(1) on Membrane-Mediated Aggregation/Oligomerization of beta-Amyloid: Unifying View
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F17%3A00478167" target="_blank" >RIV/61388955:_____/17:00478167 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.bpj.2017.03.009" target="_blank" >http://dx.doi.org/10.1016/j.bpj.2017.03.009</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bpj.2017.03.009" target="_blank" >10.1016/j.bpj.2017.03.009</a>
Alternative languages
Result language
angličtina
Original language name
Impact of GM(1) on Membrane-Mediated Aggregation/Oligomerization of beta-Amyloid: Unifying View
Original language description
In this perspective we summarize current knowledge of the effect of monosialoganglioside GM(1) on the membrane-mediated aggregation of the beta-amyloid (A beta) peptide. GM(1) has been suggested to be actively involved in the development of Alzheimer's disease due to its ability to seed the aggregation of A beta. However, GM(1) is known to be neuroprotective against A beta-induced toxicity. Here we suggest that the two scenarios are not mutually exclusive but rather complementary, and might depend on the organization of GM(1) in membranes. Improving our understanding of the molecular details behind the role of gangliosides in neurodegenerative amyloidoses might help in developing disease-modifying treatments.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
<a href="/en/project/GA17-03160S" target="_blank" >GA17-03160S: The role of gangliosides in the development of neurodegenerative amyloidogenic diseases: Molecular insights by advanced fluorescence microscopy</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biophysical Journal
ISSN
0006-3495
e-ISSN
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Volume of the periodical
113
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
1194-1199
UT code for WoS article
000411064500007
EID of the result in the Scopus database
2-s2.0-85017394553