(GM1) Ganglioside Inhibits beta-Amyloid Oligomerization Induced bySphingomyelin

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F16%3A00088531" target="_blank" >RIV/00216224:14740/16:00088531 - isvavai.cz</a>

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1002/anie.201603178/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/anie.201603178/abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/anie.201603178" target="_blank" >10.1002/anie.201603178</a>

Result language

angličtina

Original language name

(GM1) Ganglioside Inhibits beta-Amyloid Oligomerization Induced bySphingomyelin

Original language description

beta-Amyloid (A beta) oligomers are neurotoxic and implicated in Alzheimer's disease. Neuronal plasma membranes may mediate formation of A beta oligomers in vivo. Membrane components sphingomyelin and GM(1) have been shown to promote aggregation of A beta; however, these studies were performed under extreme, non-physiological conditions. We demonstrate that physiological levels of GM(1), organized in nanodomains do not seed oligomerization of A beta(40) monomers. We show that sphingomyelin triggers oligomerization of A beta(40) and that GM(1) is counteractive thus preventing oligomerization. We propose a molecular explanation that is supported by all-atom molecular dynamics simulations. The preventive role of GM(1) in the oligomerization of A beta(40) suggests that decreasing levels of GM(1) in the brain, for example, due to aging, could reduce protection against A beta oligomerization and contribute to the onset of Alzheimer's disease.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Angewandte Chemie International Edition

ISSN

1433-7851

e-ISSN

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Volume of the periodical

55

Issue of the periodical within the volume

32

Country of publishing house

DE - GERMANY

Number of pages

5

Pages from-to

9411-9415

UT code for WoS article

000383371800055

EID of the result in the Scopus database

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