Abacavir: comparison of oxidation mechanisms

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F21%3A10442136" target="_blank" >RIV/00216208:11310/21:10442136 - isvavai.cz</a>
Result on the web
<a href="http://web.natur.cuni.cz/analchem/isc/isc17.pdf" target="_blank" >http://web.natur.cuni.cz/analchem/isc/isc17.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Abacavir: comparison of oxidation mechanisms
Original language description
During forced degradation studies that are a part of the drug product development, an active substance is exposed to extreme conditions. The effect of humidity, light, pH and oxidation on the active substance is studied. The most common way to study the effect of oxidation is to expose active substance to a 0.1-3.0% solution of hydrogen peroxide. Another possibility is to use radical initiators or metal ions. An alternative method is electrochemical oxidation. The oxidation of an active substance is not only affected by the oxidation agent but also depends on the solvent. In this study, the abacavir oxidation in different solvents by different approaches is investigated. The electrochemical oxidation in flow cell was compared with peroxide mediated, radical and metal ions oxidation. Electrochemical oxidation yielded the largest variety of oxidation products from all the tested approaches.
Czech name
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Czech description
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Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings of the 17th International Students Conference "Modern Analytical Chemistry"
ISBN
978-80-7444-089-2
ISSN
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e-ISSN
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Number of pages
7
Pages from-to
73-79
Publisher name
Univerzita Karlova, Přírodovědecká fakulta
Place of publication
Praha
Event location
Prague
Event date
Sep 16, 2021
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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