Faradaic Fenton Pixel: Reactive Oxygen Species Delivery Using Au/Cr Electrochemistry
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F23%3APU149010" target="_blank" >RIV/00216305:26620/23:PU149010 - isvavai.cz</a>
Result on the web
<a href="https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202300353" target="_blank" >https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202300353</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cbic.202300353" target="_blank" >10.1002/cbic.202300353</a>
Alternative languages
Result language
angličtina
Original language name
Faradaic Fenton Pixel: Reactive Oxygen Species Delivery Using Au/Cr Electrochemistry
Original language description
Reactive oxygen species (ROS) are an integral part of many anticancer therapies. Fenton-like processes involving reactions of peroxides with transition metal ions are a particularly potent and tunable subset of ROS approaches. Precise on-demand dosing of the Fenton reaction is an area of great interest. Herein, we present a concept of an electrochemical faradaic pixel that produces controlled amounts of ROS via a Fenton-like process. The pixel comprises a cathode and anode, where the cathode reduces dissolved oxygen to hydrogen peroxide. The anode is made of chromium, which is electrochemically corroded to yield chromium ions. Peroxide and chromium interact to form a highly oxidizing mixture of hydroxyl radicals and hexavalent Cr ions. After benchmarking the electrochemical properties of this type of device, we demonstrate how it can be used under in vitro conditions with a cancer cell line. The faradaic Fenton pixel is a general and scalable concept that can be used for on-demand delivery of redox-active products for controlling a physiological outcome.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
<a href="/en/project/GA23-07432S" target="_blank" >GA23-07432S: Faraday’s Scalpel: electrochemical oxygen reduction for precise neural tissue ablation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chembiochem : a European journal of chemical biology
ISSN
1439-4227
e-ISSN
1439-7633
Volume of the periodical
24
Issue of the periodical within the volume
17
Country of publishing house
DE - GERMANY
Number of pages
14
Pages from-to
1-14
UT code for WoS article
001037281000001
EID of the result in the Scopus database
2-s2.0-85165960115