PD1+CD8+ Cells Are an Independent Prognostic Marker in Patients with Head and Neck Cancer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F22%3A10449633" target="_blank" >RIV/00216208:11310/22:10449633 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/22:10449633 RIV/00216208:11110/22:10449633 RIV/00216208:11130/22:10449633 RIV/61989592:15310/22:73616795
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=dvfzOlqEtm" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=dvfzOlqEtm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/biomedicines10112794" target="_blank" >10.3390/biomedicines10112794</a>

Result language
angličtina
Original language name
PD1+CD8+ Cells Are an Independent Prognostic Marker in Patients with Head and Neck Cancer
Original language description
Head and neck squamous cell carcinomas (HNSCCs) belong to a group of diverse tumors, which can be induced by infection with human papillomavirus (HPV) or tobacco and alcohol con sumption. The viral etiology of HNSCC relates to better clinical outcomes reflecting a different immune system response. Here, we retrospectively analyzed 97 tissue samples from oral and oropha ryngeal carcinomas associated and non-associated with HPV infection using multispectral fluorescent immunohistochemistry. To evaluate the immune cell infiltration in tumor and stroma compartments, we designed four panels of four to five antibodies. We detected more T lymphocytes in the stroma, compared to the tumor parenchyma. In HPV positive (HPV+ ) in comparison to HPV negative (HPV-) tumors, higher counts of CD3+CD4+ , CD3+CD8+ , PD1+CD4+ , PD1+CD8+ T cells, and ICOS- Treg cells were detected while more ICOS+ Treg cells and CTLA4+CD4+ T cells were observed in HPV- than in HPV+ tumors. The results of the univariate and multivariate analyses confirmed the pre dominant impact of HPV status on prognosis. More importantly, the number of CD8+PD-1+ T cells was identified as an independent factor, influencing the overall and/or disease-specific survival of patients with oral cavity or oropharyngeal carcinomas.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10607 - Virology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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