Regulatory T cells and their prognostic value for patients with squamous cell carcinoma of the head and neck
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A7929" target="_blank" >RIV/00216208:11110/10:7929 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/10:00350296 RIV/00216208:11130/10:6204 RIV/00064203:_____/10:6204
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Regulatory T cells and their prognostic value for patients with squamous cell carcinoma of the head and neck
Original language description
Regulatory T cells (Treg) are important regulators of anti-cancer immune responses. Blood samples from 112 patients with head and neck squamous cell carcinoma (HNSCC) were analysed at the time of diagnosis with emphasis on Treg counts (CD3+ CD4+ CD25+),complete blood count and tumour markers (SCC; CEA; ?1-antitrypsin; Cyfra 21?1; C-reactive protein). Data were related to TNM classification, and course of the disease 1 year after the end tretament. The percentage of CD8+ cells increased and the CD4/CD8ratio decreased with tumour grade. The ratio of B lymphocytes decreased in patients with locoregional metastases (11.25% versus 9.22%). Treg (15.2%) and CD4+ cells (45.3%) increased, while NK cells (11.8%) decreased in HNSCC patients compared to controls(9.0%, 38.1% and 15.8%, respectively). The erythrocyte counts (4.64x1012/l versus 4.45x1012/l) and haemoglobin levels (14.58 g/dl versus 14.05 g/dl) decreased, while Treg counts (8.91% versus 15.70%) increased in patients with early recu
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Cellular and Molecular Medicine
ISSN
1582-1838
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
1-2
Country of publishing house
RO - ROMANIA
Number of pages
8
Pages from-to
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UT code for WoS article
000275639700037
EID of the result in the Scopus database
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