Circadian rhythms of locomotor activity in rats: Data on the effect of morphine administered from the early stages of embryonic development until weaning
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F22%3A10452913" target="_blank" >RIV/00216208:11310/22:10452913 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=RTqmx6FZ1B" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=RTqmx6FZ1B</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.dib.2022.107812" target="_blank" >10.1016/j.dib.2022.107812</a>
Alternative languages
Result language
angličtina
Original language name
Circadian rhythms of locomotor activity in rats: Data on the effect of morphine administered from the early stages of embryonic development until weaning
Original language description
The circadian clock generates behavioural and physiological rhythms to maximize the efficacy of organismal functions. The circadian system with a major circadian pacemaker in the suprachiasmatic nucleus of the hypothalamus develops gradually and its proper function in adulthood depends on an appropriate neurochemical milieu during ontogeny [1]. Locomotor activity is under direct control by the circadian clock, and alterations in its rhythmicity indicate changes of circadian clock function. We evaluated circadian parameters of locomotor rhythms of adult male Wistar rats born to mothers that were exposed to a stable dose of 0.1 mg/ml of morphine in drinking water (36 ml water on average/day/each rat) from embryonic day 10 (E10) until weaning at postnatal day 28 (P28). Increasing the dose of morphine in drinking water was used to evaluate the changes in the rhythmic gene expression in the suprachiasmatic nucleus and in the livers of young rats at P20 [2]. At P90, we started measurement of endogenous rhythmicity for 12 days in constant darkness (DD), then we applied a 15 min light pulse at circadian time 15 (CT15) and followed the animals for the next 15 days in DD. We evaluated the magnitude of light-induced phase shift and compared the circadian parameters of free-running rhythmicity in the intervals before and after the light pulse. All data were also compared between morphine-exposed animals (M group) and controls (C group) that were not exposed to morphine. An unpaired t-test confirmed a significantly longer light-induced phase delay in M group compared with C group, a prolonged circadian period in M group in the interval after the light pulse, and greater amplitude for C group in the first interval, i.e. before the light pulse. No change in total activity counts between groups was confirmed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
<a href="/en/project/GA19-03295S" target="_blank" >GA19-03295S: Consequences of sustained morphine treatment and withdrawal on the rat brain: proteomic and functional studies</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Data in Brief [online]
ISSN
2352-3409
e-ISSN
2352-3409
Volume of the periodical
40
Issue of the periodical within the volume
February
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
107812
UT code for WoS article
000780046700005
EID of the result in the Scopus database
2-s2.0-85122619363