Urinary shedding of common DNA viruses and their possible association with bladder cancer: a qPCR-based study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F23%3A10464766" target="_blank" >RIV/00216208:11310/23:10464766 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/23:43925647 RIV/00064190:_____/23:10001114
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=I40Qc0r-fk" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=I40Qc0r-fk</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/neo_2023_220703N681" target="_blank" >10.4149/neo_2023_220703N681</a>
Alternative languages
Result language
angličtina
Original language name
Urinary shedding of common DNA viruses and their possible association with bladder cancer: a qPCR-based study
Original language description
After a decade of human urinary microbiota research, little is known about the composition of the urinary virome and its association with health and disease. This study aimed to investigate the presence of 10 common DNA viruses in human urine and their putative association with bladder cancer (BC). Catheterized urine samples were collected from patients undergoing endoscopic urological procedures under anesthesia. After DNA extraction from the samples, viral DNA sequences were detected using real-time PCR. Viruria rates were compared between BC patients and controls. A total of 106 patients (89 males and 17 females) were included in the study. Fifty-seven (53.8%) were BC patients and 49 (46.2%) had upper urinary tract stones or bladder outlet obstruction. The viruses detected in the urine were human cytomegalovirus (2.0%), Epstein-Barr virus (6.0%), human herpesvirus-6 (12.5%), human papillomavirus (15.2%), BK polyomavirus (15.5%), torque teno virus (44.2%), and JC polyomavirus (47.6%), while no adenoviruses, herpes simplex virus 1 and 2, or parvoviruses were found. There were statistically significant differences in HPV viruria rates between cancer patients and controls (24.5% vs. 4.3%, p=0.032 after adjustment for age and gender). Viruria rates increased from benign to non-muscle-invasive and muscle-invasive tumors. Patients with a history of BC have higher HPV viruria rates than controls. Whether this relationship is a causal one remains to be established by further research.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30217 - Urology and nephrology
Result continuities
Project
<a href="/en/project/NV17-29992A" target="_blank" >NV17-29992A: Genetic variability of BKV in the Czech Republic and its influence on pathogenesis of infection in kidney transplant recipients</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neoplasma
ISSN
0028-2685
e-ISSN
1338-4317
Volume of the periodical
70
Issue of the periodical within the volume
2
Country of publishing house
SK - SLOVAKIA
Number of pages
8
Pages from-to
311-318
UT code for WoS article
001070933100014
EID of the result in the Scopus database
2-s2.0-85160120592