Comparative analysis of tear cytokines in patients with glaucoma, ocular hypertension, and healthy controls

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F23%3A10465958" target="_blank" >RIV/00216208:11310/23:10465958 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/23:10465958

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=yQgxSGi9dk" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=yQgxSGi9dk</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10792-023-02763-6" target="_blank" >10.1007/s10792-023-02763-6</a>

Result language

angličtina

Original language name

Comparative analysis of tear cytokines in patients with glaucoma, ocular hypertension, and healthy controls

Original language description

Purpose:To investigate the ocular surface inflammation in patients with primary open angle glaucoma and ocular hypertension by analyzing tears and to compare findings with healthy controls.Methods:Observational case–control study. Tear samples were collected by 5 µl microcapillary tube from 24 patients with glaucoma treated by antiglaucoma drops, 9 non-treated patients with ocular hypertension and 45 healthy controls. Tears were analyzed from right eye by multiplex Bio-Plex system for the presence of 6 cytokines: IL1β, IL10, IL4, IFNγ, MIF and VEGF.Results:Significantly higher concentrations of IL1β and IL10 (glaucoma or ocular hypertension vs. healthy controls, p &lt; 0.0001), VEGF (glaucoma vs. ocular hypertension, p &lt; 0.05; ocular hypertension vs. healthy controls, p &lt; 0.02) and MIF (glaucoma vs. healthy controls, p &lt; 0.03) were detected in patients’ tears. Both patient groups have activated to a significantly lower extent the Th1 pathway represented by IFNγ than Th2 pathway represented by IL10 (p &lt; 0.001) and, at the same time, the IFNγ/IL4 ratio was significantly increased in healthy controls (p &lt; 0.001) and patients with ocular hypertension (p &lt; 0.02) compared to glaucoma individuals.Conclusion:This study shows that secretion of inflammation-related cytokines by conjunctival cells is increased in both, glaucoma and ocular hypertension patients and can be detected in their tears. Nevertheless, data indicates stronger ocular surface inflammation in non-treated follow-up patients diagnosed with ocular hypertension than in glaucoma subjects treated by antiglaucoma drops.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10600 - Biological sciences

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Ophthalmology

ISSN

0165-5701

e-ISSN

1573-2630

Volume of the periodical

43

Issue of the periodical within the volume

October

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

3559-3568

UT code for WoS article

001011184600003

EID of the result in the Scopus database

2-s2.0-85161886534