Understanding the role of nuclear lamina during the murine polyomavirus infection using microscopy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F23%3A10466072" target="_blank" >RIV/00216208:11310/23:10466072 - isvavai.cz</a>
Result on the web
<a href="https://www.mcgill.ca/gci/montreal-dna-tumour-virus-meeting-dnatv" target="_blank" >https://www.mcgill.ca/gci/montreal-dna-tumour-virus-meeting-dnatv</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Understanding the role of nuclear lamina during the murine polyomavirus infection using microscopy
Original language description
The nuclear lamina (NL) is a dense meshwork of intermediate filaments V, type A lamins (lamin A/C), type B lamins (lamin B1 and B2) and membrane associated proteins. NL is located closely adjacent to the nucleoplasmic side of the inner nuclear membrane. It maintains the shape and integrity of the nucleus and plays important role in fine-tuning of DNA related processes e.g., replication and transcription and has been suggested to play a role in cell defense against pathogens. For viruses replicating in the nucleus, NL represents a natural barrier that restricts translocation of their genomes to the nucleus during entry or prevents virus progeny exit from the nucleus late times post-infection. Viruses had evolved different mechanisms to overcome this obstacle by affecting NL integrity or its composition. We followed a possible role of NL in the murine polyomavirus infection (MPyV).
Czech name
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Czech description
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Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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