The detection of hypoxia markers in non-HPV and HPV-associated head and neck cancers: implications to patient survival

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F23%3A10470058" target="_blank" >RIV/00216208:11310/23:10470058 - isvavai.cz</a>
Result on the web
<a href="http://www.ccsss.cz/index.php/ccsss/issue/view/41/" target="_blank" >http://www.ccsss.cz/index.php/ccsss/issue/view/41/</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The detection of hypoxia markers in non-HPV and HPV-associated head and neck cancers: implications to patient survival
Original language description
In the microenvironment of growing solid tumors, oxygen level often decreases and a hypoxic state is induced. This can lead to a worse treatment response and poor patient prognosis. One of the hypoxia-responsive genes is aspartate-β-hydroxylase(ASPH), whose activity promotes the growth, invasiveness, and metastasis of many solid tumors1. Head and neck cancers (HNC) are highly heterogeneous. A proportion of HNC is induced by high-risk human papillomavirus (HPV) infections and is associated with better patient outcomes compared to patients with tumors linked to tobacco and alcohol abuse.
Czech name
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Czech description
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Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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