Absence of 5' methylguanosine cap in postreplicative genes' transcripts of Vaccinia virus

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F23%3A10470080" target="_blank" >RIV/00216208:11310/23:10470080 - isvavai.cz</a>
Result on the web
<a href="http://www.ccsss.cz/index.php/ccsss/issue/view/41/" target="_blank" >http://www.ccsss.cz/index.php/ccsss/issue/view/41/</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Absence of 5' methylguanosine cap in postreplicative genes' transcripts of Vaccinia virus
Original language description
The Vaccinia virus (VACV) played a pivotal role in the discovery of the 5' mRNA. Over the past decades, VACV investigation has contributed extensively to understanding the mechanism behind 5' mRNA cap synthesis. In this study, we conducted a comprehensive analysis of VACV transcripts at the level of individual mRNA molecules. Surprisingly, our findings reveal that postreplicative VACV mRNAs, which incorporate nontemplated 5' poly(A) leaders, lack the conventional 5' cap structure in vivo.
Czech name
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Czech description
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Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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