DNA from BK polyomavirus is sensed during infection of reservoir cells via cGAS-STING pathway
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F24%3A10479610" target="_blank" >RIV/00216208:11310/24:10479610 - isvavai.cz</a>
Result on the web
<a href="https://www.toll2024.org/abstract-e-book/" target="_blank" >https://www.toll2024.org/abstract-e-book/</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
DNA from BK polyomavirus is sensed during infection of reservoir cells via cGAS-STING pathway
Original language description
Human polyomaviruses (HPyVs) include 14 species that cause primary asymptomatic infections after which the virus persists in the host by a mechanism that is not well understood. Reactivation of the infection in immunosuppressed patients leads to severe disease. Recently, it has been suggested that moderate innate immune responses in reservoir cells contribute to viral persistence. For BK polyomavirus (BKPyV), cells from the urinary tract are thought to act as viral reservoirs.Here, we investigated the potential role of the cGAS-STING signalling pathway in the interferon (IFN) responses launched by primary microvascular endothelial cells from bladder (HMVECs bd) in response to BKPyV infection.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
10607 - Virology
Result continuities
Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů