Understanding the interplay between BK polyomavirus and celular restriction factors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F24%3A10486088" target="_blank" >RIV/00216208:11310/24:10486088 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Understanding the interplay between BK polyomavirus and celular restriction factors
Original language description
The most important human polyomavirus are the Merkel cell polyomavirus, the etiological agent of 80% of Merkel cell carcinoma, JCPyV that causes progressive multifocal leukoencephalopathy and BKPyV which causes nephropathy. After initial primary infection and dissemination in the organism, persistence of polyomavirus is, by not well-known mechanism. Local innate immune response and other cellular restriction factors such as macromolecular protein complexes such as the PML nuclear bodies (PML NB) can play a role in the outcome of the infection and promote viral persistency. Our reseach focus on the understanding the molecular mechanisms of innate immune response activation and modulation in response BKPyV.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
10607 - Virology
Result continuities
Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů