Investigation of BKPyV life cycle, activation of innate immune responses and membrane remodeling in microvascular endothelial cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F24%3A10486112" target="_blank" >RIV/00216208:11310/24:10486112 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Investigation of BKPyV life cycle, activation of innate immune responses and membrane remodeling in microvascular endothelial cells
Original language description
Polyomaviruses (PyVs) are small double-stranded DNA viruses that occur widely in nature. Among the 14 known human PyVs, three are particularly relevant: BK Polyomavirus (BKPyV), JC polyomavirus, and Merkel cell carcinoma Polyomavirus. BKPyV, with a global prevalence of approximately 80% in adults, typically causes asymptomatic primary infection. After initial infection, it disseminates via the bloodstream and establishes persistence in the urinary tract. Reactivation of BKPyV can occur in immunocompromised patients, leading to complications such as nephritis or graft loss1-2. Unfortunately, there are currently no specific antiviral treatments available for BKPyV infection.
Czech name
—
Czech description
—
Classification
Type
O - Miscellaneous
CEP classification
—
OECD FORD branch
10607 - Virology
Result continuities
Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů