Monocyte cell death induced by sting agonists combines apoptosis, pyroptosis and caspase 8 activation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F24%3A10486091" target="_blank" >RIV/00216208:11310/24:10486091 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Monocyte cell death induced by sting agonists combines apoptosis, pyroptosis and caspase 8 activation
Original language description
The cyclic GMP GMP-AMP synthase - stimulator of interferon genes (cGAS cGAS-STING) pathway recognizes double double-stranded DNA in cytoplasm. Activation of the pathway induces secretion of proinflammatory cytokines and subsequently regulates immune mechanisms. The pathway can also be triggered by small molecule molecule-based STING agonists. As such, the cGAS cGAS-STING pathway is of therapeutic interest in the field of viral infections and cancer Importantly, activation of the cGAS cGAS-STING pathway can also lead to cell death regulated 3 We previously demonstarted that STING agonists induce apoptosis in human monocytes, however, the precise processes involved are still under investigation.
Czech name
—
Czech description
—

Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)