STING agonists induce monocyte depletion with characteristics of multiple regulated cell deaths
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F23%3A10466315" target="_blank" >RIV/00216208:11310/23:10466315 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
STING agonists induce monocyte depletion with characteristics of multiple regulated cell deaths
Original language description
Double-stranded DNA and cyclic dinucleotides activate the cyclic-GMP-AMP synthase - stimulator of interferon genes (cGAS-STING) pathway, which leads to the production of type I interferons (IFNs) and proinflammatory cytokines by immune cells. These compounds further mediate numerous regulatory immune processes with antiviral or antitumoral properties. Therefore, activators of the cGAS-STING pathway are being investigated for their therapeutic potential.To better understand the immune orchestration induced by STING agonists, we investigated their effect on peripheral blood mononuclear cells (PBMCs), a physiologically relevant complex of immune populations. We demonstrated that STING agonists induce the secretion of a broad portfolio of proinflammatory cytokines. However, treatment with STING agonist is also associated with robust monocyte depletion.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů