STING agonist-induced CD14+ monocyte depletion involves multiple regulated cell death mechanisms

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F23%3A00582968" target="_blank" >RIV/61388963:_____/23:00582968 - isvavai.cz</a>
Result on the web
<a href="http://www.ccsss.cz/index.php/ccsss/issue/view/38" target="_blank" >http://www.ccsss.cz/index.php/ccsss/issue/view/38</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
STING agonist-induced CD14+ monocyte depletion involves multiple regulated cell death mechanisms
Original language description
The immune cells respond to the double-stranded DNA (dsDNA) or cyclic dinucleotide (CDN)-mediated stimulation of the cyclic-GMP-AMP synthase – stimulator of interferon genes (cGAS-STING) pathway by secretion of type I interferons (IFNs) and proinflammatory cytokines. STING agonists also cause a complete depletion of CD14+ monocytes in peripheral blood mononuclear cells (PBMCs). We investigate the cell death mechanisms induced by the cGAS-STING pathway activation focusing on the combination of pyroptosis, apoptosis and necroptosis, so called PANoptosis, demonstrating that CD14+ monocyte cell death could further mediate activation of secondary immune processes including the adaptive immune mechanisms.
Czech name
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Czech description
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Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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