Dietary influence and immune balance: Regulating CD4+IEL responses and MHCII in the gut

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F25%3A10497416" target="_blank" >RIV/00216208:11310/25:10497416 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=rl4L0ql3Yg" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=rl4L0ql3Yg</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mucimm.2024.12.011" target="_blank" >10.1016/j.mucimm.2024.12.011</a>

Result language
angličtina
Original language name
Dietary influence and immune balance: Regulating CD4+IEL responses and MHCII in the gut
Original language description
Over the past decade, interest in CD4 positive intraepithelial lymphocytes (IELs) has been growing. This subset of long-overlooked helper T cell plays critical roles in intestinal homeostasis and in responses to intestinal infections. Located in the interface of the gut, this subset includes T cells reactive to both microbial-derived and food antigens. However, microbial stimulation seems to be indispensable for their maturation. The major regulator of CD4+ CD8αα+ cells in the IEL compartment is MHCII-mediated antigen presentation by intestinal epithelial cells (IECs) and epithelial MHCII is induced only by certain commensal bacterial strains under physiological conditions.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30102 - Immunology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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