Hydrophilic polymer conjugates bearing protoporphyrin IX precursors for photodynamic therapy of tumors

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F25%3A10501899" target="_blank" >RIV/00216208:11310/25:10501899 - isvavai.cz</a>

Result on the web

<a href="https://sitelf.it/2nd-sitelf-national-phd-summer-school-xxiv-adritelf-national-phd-school-2nd-4th-september-2025-palermo/" target="_blank" >https://sitelf.it/2nd-sitelf-national-phd-summer-school-xxiv-adritelf-national-phd-school-2nd-4th-september-2025-palermo/</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Hydrophilic polymer conjugates bearing protoporphyrin IX precursors for photodynamic therapy of tumors

Original language description

Photodynamic therapy is an advantageous approach in anticancer treatment, mostly due to its non-invasive character. It consists of three main components - photosensitizer, light and oxygen. After photosensitizer administration, irradiation of the tumor tissue with light of appropriate wavelength takes place resulting in singlet oxygen production and tumor death. Photosensitizers are molecules based predominantly on porphyrins or similar structures with protoporphyrin IX (PPIX) being an endogenous photosensitizer. PPIX is usually administered in form of a prodrug, 5-aminolevulinic acid (5-ALA), which gets metabolized to PPIX intracellularly. Nevertheless, 5-ALA lacks tumor targeting properties, gets distributed among the whole body, and is excreted rapidly. To overcome such poor pharmacokinetics, conjugation to water soluble polymer-based drug delivery system was performed. Water soluble polymer-drug conjugates are known to be targeted to the tumor tissue by the enhanced permeability and retention (EPR) effect, which is based on the leaky tumor vasculature and absence of the lymphatic drainage within the tumor. An advantageous material for water soluble polymer conjugates is poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA), mostly due to its biocompatibility and controlled synthesis.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

10404 - Polymer science

Project

<a href="/en/project/LX22NPO5102" target="_blank" >LX22NPO5102: National institute for cancer research</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů